81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor hinein a physiologically normal pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.
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Leichte zweirädrige Kraftfahrzeuge mit einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht mehr denn 45 km/h, einer Nenndauerleistung/Nutzleistung von nicht etliche denn 4 kW und einem Verbrennungsmotor mit einem Hubraum von nicht etliche als 50 cm³ oder einer anderen Antriebsform.
We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of our research.
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We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to hinein vivo models and life imaging.
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.
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If you are lacking driving practice or simply haven't driven a car in a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
We will give you driving lessons designed to suit your own particular needs not only during the week but also on Saturdays. Hinein this way you will get your driving licence as quickly as possible.
Der markante Eigenheim mit den drei hohen Türmen wurde aus massiven Sandsteinblöcken erbaut zumal besitzt eine dekorative Rosette des weiteren ein Giebeldach.
If you are lacking driving practice or simply haven't driven a car hinein a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
Next to the Ostfriedhof bus and tram stop Can I take a trial lesson rein the theoretical course hinein order to get an impression of the atmosphere?
Where can I find an economical first-aid course? We also offer courses daily rein the Munich city area. They are all held rein classrooms adjacent to U/S-Bahn stations. Moosach
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